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Researchers
  • Prof.  Michael Tal
 
Born 1947, Jerusalem;
D.M.D. 1975, Hebrew Univ.;
M.S. 1978, Univ. of California, Los Angeles; Lect. 1979;
Sen. Lect. 1988;
Assoc. Prof. 1996,
Professor 2005.
President Israel Pain association, Academic
Director of the Center for Research on Pain of The Hebrew University-Hadassah .
Head Pain Research laboratory.
Prof. Tal is a laboratory head and the Director of the Center for Research on pain. Past President of the Israel Pain Association. His higher education was at Hebrew University (DMD) and UCLA (MS). He had worked with Gary Bennett at NIH with Ron Dubner and Ken Ren In Baltimore Maryland and recently at the Department of Neurosurgery in Johns Hopkins Baltimore . His laboratory has published in the pain field, with work of a notably integrative nature involving neurophysiology, psychophysiology and animal behavior.

Research Interest

 
  • Mechanisms of neuropathic pain after nerve injury. Mechanisms whereby injury evokes sensory dysfunction and chronic pain. Pathophysiology of injured nerve, particularly, abnormal discharge originates at the site of nerve injury or in the DRG in experimental animal models for neuropathy in the rat.
  • Relationship between sensory and motor modalities in the oro-facial area. Effects and mechanisms of different drugs and hypnosis on pain and reflexes in the oro-facial area.

Research Projects

  • Phenotypic switch as a mechanisms underlying A-beta pain.
  • The relationship between the Cytokine IL-1 and LTP in the dorsal horn of the spinal cord.

Public activity

Past President of the Israel Pain association. Director of the Center for Research on pain of the Hebrew University.
 

Recent Publications

  • Sharav, Y., Tal. M.: (2004) Focused analgesia and generalized relaxation produce differential hypnotic analgesia in response to ascending stimulus intensity. Int. J Psychophysiology. 52/2:187-196.
  • Cherkas,P.S., Huang, T.Y., Pannicke, T., Tal, M. , Reichenbach A., Hanani, M .:(2004) . The effects of axotomy on neurons and satellite glial cells in mouse trigeminal ganglion. Pain 110(1-2):290-8.
  • Gabay. E, and Tal. M.: (2004) Pain behavior and nerve electrophysiology in the CCI model of neuropathic pain. Pain 110(1-2):354-360).
  • Eliav, E., Tal, M, and R., Benoliel.: (2004) Experimental malignancy in the rat induces early hypersensitivity indicative of neuritis. Pain 110(3):727-37.
  • Tal. M. , Sharav,Y. (2005) Jaw clenching modulates sensory perception in- high but not low- hypnotizable subjects. J Orofacial Pain 19:76-81.
  • Tal. M., Sharav,Y. (2005) Jaw clenching modulates sensory perception in- high but not low- hypnotizable subjects. J Orofacial Pain 19:76-81.
  • Sharav and Tal- Sharav, Y. and Tal, M.: (2006) Focused hypnotic analgesia: local and remote effects. Pain. 124(3):280-286.
  • Michael Tal, Junesun Kim, Seung Keun Back, Heung Sik Na, and Marshall Devor.: Onset of Ectopic Firing in the Chung Model of Neuropathic Pain Coincides with the Onset of Tactile Allodynia. Proceedings of the 11th World Congress on Pain-IASP, Ed. H. Flor. IASP Press 2006,119-130.
  • Wolf, G., Gabay, E., Tal, M., Yirmiya, R., Shavit, Y. (2006) Impairment of Interleukin-1 (IL-1) Signaling Attenuates Neuropathic Pain and Spontaneous Ectopic Neuronal Activity Following Nerve Injury. Pain 120:315-324
  • Sharav, Y. and Tal, M.: (2006) Focused hypnotic analgesia: local and remote effects. Pain. 124(3):280-286.
  • Benoliel, R., Tal, M. and Eliav, E. (2006) Effects of Topiramate on the Chronic Constriction Injury Model in the Rat. The Journal of Pain, 7; 12: 878-883.
  • Kleibeuker, W, Gabay, E., Kavelaars, A., Zijlstra, J., Wolf, G., Ziv, N., Yirmiya, R.,Shavit, Y., Tal, M., and Heijnen, C. J.: (2008). IL-1a signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2. Brain Behav. Immun. 22(2):200-8
  • Dan Kaufmann, Boris Yagen Anne, Minert, Michael Tal, Marshall Devor and Meir Bialer. (2008) Evaluation of the Enantioselective Antiallodynic and Pharmacokinetic Profile of Propylisopropylacetamide, a Chiral Isomer of Valproic Acid Amide. Neuropharmacology 54(4):699-707.
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