Patents and awards:
Patents (US - Israel - Europe ) The clinical use of sustained release local delivery systems for the treatment of periodontal disease.
Kaye Innovation Award for the development of Perio-chip - Hebrew University (2002 )
Applied Research and Development:
The biological development of sustained release local delivery systems for the treatment of periodontal disease - Perio-chip manufactured by Dexon pharmaceutics (1987-todate) .
Microbial etiology of periodontal disease.
Etiology and Treatment of Aggressive periodontal Disease
Molecular aspects of bacterial coaggragation in the oral biofilm.
The effect of salivary and serum components on biofilm formation on Implants.
Bimstein E, Ram D, Irshied J, Naor R, Sela MN . Periodontal diseases, caries, and microbial composition of the subgingival plaque in children: a longitudinal study. ASDC J Dent Child;69(2):133-7, 123, 2002.
Rosen, G. and M.N. Sela .. Porphyromonas gingivalis lipopolysaccharide and capsular polysaccharide are adhesins mediating coaggregation with Fusobacterium nucleatum. Abst. 29091, JDR, (2003).
Sela, M.N ., Kohavi, D., Krausz, E.,Steinberg, D. & Rosen, G. Enzymatic Degradation of Collagen Guided Tissue Regeneration Membranes by Periodontal Bacteria. Clin. Oral Imp. Res. 14:263-268 2003.
Rosen G., Nisimov I. , Helcer M ., Sela M.N . Actinobacillus actinomycetemcomitans Serotype b Lipopolysaccharide Mediates Coaggregation with Fusobacterium nucleatum. Infection and Immunity. 71: 3652-3656, 2003.
Bachrach G, Rosen G, Bellalou M, Naor R , Sela MN . Identification of a Fusobacterium nucleatum 65 kDa serine protease. Oral Microbiol Immunol.19:155-159, 2004.
H.D. Segan Cohen , M.N. Sela , M. Angie, and M. Mosseri Association between Dental Caries Activity and Coronary Heart Disease Severity. The IADR/AADR/CADR 83rd General Session (2005).
M.N. Sela , L Badihi , D. Kohavi, G. Rosen, and D. Steinberg Biological Effects of Modifications of Titanium Implant Surfaces Annual Meeting of the Israeli Division of the International Association for Dental Research (2005).
Graciela Rosen, Michael N. Sela Coaggregation of Porphyromonas gingivalis and Fusobacterium nucleatum PK 1594 is mediated by capsular polysaccharide and lipopolysaccharide FEMS Microbiology Letters 256 (2), 304–310, 2006.
Michael N. Sela , Liad Badihi , Graciela Rosen, Doron Steinberg, David Kohavi Adsorption of human plasma proteins to modified titanium surfaces
Clin Oral Implants Res . 18(5):630-638, 2007.
O. Oettinger-barak , H. Sprecher , MN Sela , and EE Machtei Periodontal Pathogens and Localized Aggressive Periodontitis In Israel Annual Meeting of the Israeli Division of the International Association for Dental Research (2008) .
Rosen, Graciela; Genzler, Tamar; Sela, Michael N . Coaggregation of Treponema denticola with Porphyromonas gingivalis and Fusobacterium nucleatum is mediated by the major outer sheath protein of Treponema denticola FEMS Microbiology Letters , Volume 289, Number 1, December, pp. 59-66, 2008 .
Sela MN, Babitski E, Steinberg D, Kohavi D, Rosen G. Degradation of collagen-guided tissue regeneration membranes by proteolytic enzymes of Porphyromonas gingivalis and its inhibition by antibacterial agents. Clin. Oral Impl. Res. 2009, 20; 496–502.
G. Nussbaum, S. Ben-Adi, T. Genzler, M.N. Sela, and G. Rosen Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components Infection and Immunity, September 2009, p. 3939-3947, Vol. 77, No. 9