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Researchers
  • Prof.  Doron Steinberg
 
Born 1955, Jerusalem
Ph.D. 1988, Hebrew University.
Lect. 1992
Sen. Lect. 1999
Assoc. Prof. 2003
Full Prof 2007
Director:  Biofilm Research Laboratory 
 
Academic Position Head, Bio-Medicine Graduate Program in Dental Medicine 
 
Research InterestsBiofilms: formation, composition, properties and prevention.
Biofilms: gene expression, bacteria-bacteria communication (quorum sensing)
Development of drugs, drug delivery systems and sustained released devices affecting biofilms.
Fields of biofilm research: dental, medicinal, water systems, Clean Tec, food technology 
 
Research ProjectsModulation of bacteria-bacteria communication (quorum sensing).
Gene expression of bacteria in biofilm.
Properties of cell free constituents of biofilms compared to planktonic conditions.
Biochemical properties of oral bacteria in biofilm compared to solution.
Novel medications (e.g., sustained release devices) affecting biofilms (human  veterinarian use and engineering applications).
Biofilm properties on dental materials and implants.
Novel approaches in affecting biofilms in water systems, medical devices, & house hold.
Development of models for various biofilms 
  
Abstracts of Current Research Biofilms:
Most bacteria in nature are associated in biofilms. Biofilms are unique environments which harbor the main virulent factors which trigger most diseases. The biological, biochemical properties and gene expression of immobilized bacteria in the biofilm may differ than of bacteria in solution. Enzymatic properties of cell free enzymes may differ also in these two distinct environments. Bacteria in biofilms communicate via autoinducers - allowing better acclimation to the biofilm micro environment.
We have developed models that mimic the micro-environment of various types of biofilms. Significant clinical, biological, pharmaceutical and pharmacological information can be obtained from studying constituents of the biofilms in such models. Recently we have synthesized chemical analogues of the natural autoinducers allowing us to manipulate communication between bacteria.
Novel drugs and drug delivery systems are developed and tested in my laboratory as a major means to affect biofilms.
 
Key words: biofilm, sustained release delivery systems  
 
 
Selected Publications
Cohen J, Featherstone JD, Le CQ, Steinberg D, Feuerstein O. Effects of CO2 laser irradiation on tooth enamel coated with biofilm. Lasers Surg Med. 2014 Jan 7. doi: 10.1002/lsm.22218. [Epub ahead of print]
 
Kagan S, Jabbour A, Sionov E, Alquntar AA, Steinberg D, Srebnik M, Nir-Paz R, Weiss A, Polacheck I. (2014) Anti-Candida albicans biofilm effect of novel heterocyclic compounds. J Antimicrob Chemother. 69:416-27.
 
Kohavi D, Badihi L, Rosen G, Steinberg D, Sela MN. (2013) An in vivo method for measuring the adsorption of plasma proteins to titanium in humans. Biofouling. 29:1215-24.
 
Helft, S., Stabholtz, A., Moshonov, J., Gutkin, V., Redenski, I., Steinberg, D.  (2013).  Effect of Er:YAG laser-activated irrigation solution on Enterococcus faecalis biofilm in ex-vivo root canal model .  Photomedicine and Laser Surgery. Photomed Laser Surg. 31(7):334-41.
 
Lorber, G., Duvdevani, M., Friedman, M., Lavy, E., Landau, EH., Gofrit, ON., Pode, D., Steinberg D. (2013). Sustained Release Antibacterial Varnish Coated Biopsy Needle For Reduction of Infection Rates Following Prostate Biopsy - In vitro Model. J Endourol . 27(3):277-83.
 
Zelichenko, G., Steinberg, D., Lorber, G., Friedman, M., Zaks, B., Lavy, E., Hidas, G., Landau, HE., Gofrit, ON., Pode, D., Duvdevani,  M. (2013). Prevention of Initial Biofilm Formation on Ureteral Stents Using a Sustained Releasing Varnish Containing Chlorhexidine: In vitro Study. J Endourol. 27(3):333-7.
 
Sol, A., Steinberg, D., Featherstone, JDB., Feuerstein, O. (2013). Changes in gene expression of Streptococcus mutans in planktonic environment following CO2 laser irradiation.  Photomedicine and Laser Surgery. 31(3):139-45.
 
Shapur , NK., Duvdevani,  M., Friedman,  M., Zaks,  B., Gati, I., Lavy, E., Katz, R., Landau, EH., Pode, D., Gofrit, ON., Steinberg, D. (2012). Sustained releasing varnish containing chlorhexidine for prevention of biofilm formation on urinary catheter surface: in vitro study. J Endourol. 26:26-31.
 
Chebath-Taub, D., Steinberg, D., Featherstone, JD., Feuerstein, O. (2012). Influence of blue light on Streptococcus mutans re-organization in biofilm. Photochem Photobiol B. 116:75-8.
 
Lavy, E., Ezroni, G., Friedman, M.  Steinberg, D. (2012). Novel local sustained released varnish for reducing oral bacteria in dogs. Isr J Vet Med. 67:147-53.
 
Lavy, E., Goldberger, D.,  Friedman, M., Steinberg D. (2012). pH values and mineral content of saliva in different breeds of dogs. Isr J Vet Med. 67:244-48.
 
Vered, Y., Zini, A., Mann, J., Kolog, H., Steinberg, D. , Zambon, JJ., Haraszthy, VI., Devizio, W., Sreenivasan, P. (2011), Teeth and implant surroundings: clinical health indices and microbiologic parameters. Quintessence Int. 42:339-44.
 
Erdem, AP., Sepet, E., Avshalom, T., Gutkin, V., Steinberg, D. (2011), Effect of CPP-ACP and APF on Streptococcus mutans biofilm: A laboratory study. Am J Dent. 24:119-23.
 
Sol, A., Feuerstein, O., Featherstone,  J.,  Steinberg, D. (2011). Effect of sub-lethal CO2 laser irradiation on gene expression of Streptococcus mutans immobilized in a biofilm. Caries Res.  20;45:361-9.
 
Hidas, A., Noy, AF., Birman, N., Shapira, J., Matot, I., Steinberg, D., Moskovitz M. (2011). Oral health status, salivary flow rate and salivary quality in children, adolescents and young adults with ADHD. Arch Oral Biol. 56:1137-41.
 
Bachrach, G.,  Jamil, A., Naor, R., Tal, G., Ludmer, Z., Steinberg, D. (2011). Garlic allicin as a potential agent for controlling oral pathogens. J. Med. Food 14:1338-43.
 
Sahar-Helft, S., Slutzky-Goldberg, I., Moshonov, J., Stabholtz, A., Jacobovitz, M., Tam, A.,  Steinberg, D. (2011). Synergistic effect of Er:Yag laser irradiation in combination with chlorhexidine on the viability of Enterococcus faecalis – An in-vitro study. Photomed Laser Surg. 29:753-8.
 
Czerninski, R., Sivan, S., Steinberg, D., Gati, I., Kagan, L., Friedman M. (2010). A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clin Oral Investig. 14:71-88.
 
Shemesh, M., Tam, A., Aharoni A., Steinberg D. (2010). Genetic adaptation of Streptococcus mutans during biofilm formation on different types of surface. BMC Microbiol. 18;10:51.
 
 
Feldman M., Weiss EI., Ofek I., Shemesh M., Steinberg,  D.  (2010). In vitro real-time interactions of cranberry constituents with immobilized fructosyltransferase J Medicinal Food. 13:11530-60.
 
Sreenivasan, PK., Vered, Y., Zini, A., Mann, J., Kolog, H., Steinberg, D., Zambon, JJ. , Haraszthy, VI., Da Silva, MP. De Vizio, W.  (2010). A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants.  J Clin Periodontol. 38:33-42.
 
Feldman, M., Weiss, E., Shemesh, M., Ofek, I., Bachrach, G., Rozen, R., Steinberg, D. (2009). Cranberry constituents affect fructosyltransferase expression in Streptococcus mutans. Altern Ther Health Med. 15:32-38.
 
Feldman, M., Weiss, EI., Ofek, I., Steinberg, D. (2009). Interference of cranberry constituents in cell-cell signaling system of Vibrio harveyi. Curr Microbiol. 59:469-74.
 
Aharoni, R., Bronstheyn, M., A. Jabbour, A., B. Zaks, B., Srebnik, M., Steinberg, D. (2008). Oxazaborolidine derivatives inducing Autoinducer-2 signal transduction in Vibrio harveyi. Bioorganic. & Med. Chem. 16:1596-1604.  
 
Bachrach, G., Altman, H., Kolenbrander, PE., Chalmers, NI., Gabai-Gutner, M., Mor, A., Friedman, M., Steinberg, D. (2008). Resistance of Porphyromonas  gingivalis ATCC 33277 to direct killing by antimicrobial peptides is protease independent. Antimicrob Agents and Chemother. 52:638-642.
 
Steinberg, D., Moreinos, D., Featherstone, J., Shemesh, M. and Feuerstein, O. (2008). Genetic and physiological effects of noncoherent visible light combined with hydrogen peroxide on Streptococcus mutans in biofilm. Antimicrob. Agents and Chemother.  52:2626-2631. 
 
Shemesh, M., Tam, A., Kott-Gutkowsk, M., Feldman M. and Steinberg, D. (2008). DNA-microarrays identification of Streptococcus mutans genes associated with biofilm thickness. BMC Microbiology. 29;8:236.
 
Jabbour, A, Shemesh, M., Srebnik, M., Zaks, B., Steinberg, D. (2007). Effect of oxazaborolidines on immobilized fructosyltransferase analyzed by surface plasmon resonance. Biosens. Bioelectron. 15:1658-663. 
 
Shemesh, M., Tam, A. and Steinberg, D. (2007). Differential gene expression profiling of Streptococcus mutans cultured under biofilm and planktonic conditions. Microbiology SGM 153:1307-1317.
 
Sela, MN.PI #, Badihi, L., Rosen, G. , Steinberg, D. # and Kohavi, D. # (2007). Adsorption of human plasma proteins to modified Titanium surfaces. Clin. Oral Implan. Res. 18: 630-638. (# Equal contribution of PIs 
 
Shemesh, M., Tam, A. Steinberg, D. (2007). Expression of biofilm associated genes of Sterptococcus mutans in response to glucose and sucrose. J.  Med. Microbiol. 56:1528-1535.
  
 
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