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Researchers
  • Prof.  Dan Gazit
 
Curriculum Vitae
Name:    Dan Gazit           
Place of Birth:    Jerusalem, Israel 
Marital Status:   Married; 6 children.
EDUCATION
Ph.D.    (1991)  Hebrew University of Jerusalem
D.M.D.  (1976) Hebrew University of Jerusalem
ACADEMIC APPOINTMENTS:
2002- present  Professor, Hebrew University of Jerusalem.
1998- 2002        Associate Professor, Hebrew University of Jerusalem.
1992- 1998       Tenured Senior lecturer in Oral Pathology, Hebrew University of     Jerusalem
1986                    Lecturer in Oral Pathology, Hebrew University of Jerusalem
1981-1985          Instructor in Oral Pathology, Hebrew University of  Jerusalem.
UNIVERSITY APPOINTMENTS
2012-2014 Member, Tenure Faculty Appointments Committee, Hebrew University of Jerusalem
2010-present Member, Experimental Sciences Faculty Appointments and Promotions Committee, Hebrew University of Jerusalem
2005-present Member, Executive Committee of the Hebrew University Board of Governors
2005-present Chair, Research Committee, Faculty of Dental Medicine, Hebrew University of Jerusalem
2005-2010 Director, Hebrew University of Jerusalem Center for Converging Sciences and Technologies
2002-2003 Member, Rector’s committee for the foundation of graduate    school, The Hebrew University of Jerusalem.
2002-2003 Member, Dean of Students Committee, The Hebrew  University of     Jerusalem
2001-2003 Chairman, Biotechnology Steering Committee, The Hebrew      University of Jerusalem
1999-2004 Member, Steering Committee, Gene Therapy Center,  Hadassah Medical Center, Jerusalem
1998-2003 Chairperson, Faculty Research Day, The Hebrew University of  Jerusalem
1997-2003 Head, Hebrew University Dental Sciences Graduate Program
1996-2001 Head, Oral Pathology Biopsy Facility, The Hebrew University - Hadassah Faculty of Dental Medicine
1994-1998 Representative of Senior Lecturers and Associate Professors to the Senate of the Hebrew University of Jerusalem
1984-1985 Representative of Instructors to the Faculty Council, the Hebrew University-Hadassah School of Dental Medicine
VISITING POSITIONS
2003-2010  Visiting Professor, University of Virginia School of Medicine
1999 Visiting Professor, Harvard Medical School, Bone Biology Research
1999 Visiting Professor, Boston University, Bone Biology Research
1999 Visiting Professor, Leiden Medical Center, Bone Biology Research

RESEARCH INTERESTS
• Skeletal gene therapy & regenerative medicine.
• Stem cell isolation and characterization.
• Novel gene discovery.
• Nano technology in regenerative medicine.
• Molecular & Micro Imaging.
  
 
PUBLICATIONS (LAST FIVE YEARS)
• Pelled G, Ben Arav A, Hock C, Reynolds DG, Yazici C, Zilberman Y, Gazit Z, Awad H, Gazit D, Schwarz E. Direct gene therapy for bone regeneration: gene delivery, animal models and outcome Measures.  Tissue Eng Part A. 2010;16(1):13-20.
• Saar G, Zilberman Y, Shinar H, Keinan-Adamsky K, Pelled G, Gazit D, Navon G. Monitoring of the effect of intervertebral disc nucleus pulposus ablation by MRI. NMR in Biomedicine. 2010; 23(6):554-62
• Sheyn D, Mizrahi O, Benjamin S, Gazit Z, Pelled G, Gazit D. Genetically modified cells in regenerative medicine and tissue engineering. Adv Drug Deliv Rev. 2010; 62(7-8):683-698.
• Song J, Reichert S, Kallai I, Gazit D, Wund M, Boyce MC, Ortiz C. Quantitative microstructural studies of the armor of the marine threespine stickleback (Gasterosteus aculeatus). J Struct Biol. 2010; 171(3):318-31
• Garty S, Kimelman-Bleich N, Hayouka Z, Cohn D, Friedler A, Pelled G, Gazit D. Peptide-modified ”smart” hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules. 2010; 11(6):1516-1526 .
• Kallai I, van Lenthe H, Ruffoni D, Zilberman Y, Müller R, Pelled G, Gazit D. Quantitative, structural and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells. J Biomech. 2010; 43(12):2315-20.
• Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study. Tissue Eng Part A. 2010; 16(11): 3403-3412.
• Sheyn D, Rüthemann M, Mizrahi O, Kallai I, Zilberman Y, Tawackoli W, Kanim LE, Zhao L, Bae H, Pelled G, Snedeker J, Gazit D. Genetically modified mesenchymal stem cells induce mechanically stable posterior spine fusion. Tissue Eng Part A. 2010;16(12):3679-86.
• Kimelman-Bleich N, Seliktar D, Kallai I, Helm GA, Gazit Z, Gazit D, Pelled G. The effect of ex vivo dynamic loading on the osteogenic differentiation of genetically engineered mesenchymal stem cell model. J Tissue Eng Regen Med. 2011;5(5):384-93.
• Smith BJ, Sutton GM, Wu X, Yu G, Goh BC, Hebert T, Pelled G, Gazit Z, Gazit D, Butler AA, Gimble JM. Ovariectomy and genes encoding core circadian regulatory proteins in murine bone. Osteoporosis Osteoporos Int. 2011; 22(5):1633-9.
• Kimelman-Bleich N, Pelled G, Zilberman Y, Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Gazit D. Targeted Gene-and-host Progenitor Cell Therapy for Nonunion Bone Fracture Repair. Mol Ther. 2011;19(1):53-9.
• Zhang Y, Gazit Z, Pelled G, Gazit D, Vunjak-Novakovic G. Patterning osteogenesis by inducible gene expression in microfluidic culture systems. Integr Biol (Camb). 2011;3(1):39-47.
• *Gazit Z, Pelled G, Sheyn D, Kimelman N, Gazit D.  “Mesenchymal Stem Cells”, in Principles of Regenerative Medicine, 2nd edition,  Atala A, Lanza R, Thomson JA, and Nerem RM. Eds.  Elsevier Inc.  2011.
• Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Pelled G, Gazit D. Micro–computed tomography–based structural analysis of various bone-tissue regeneration models. Nat Protoc. 2011;6(1):105-10.
• Sheyn D, Kallai I, Tawackoli W, Cohn Yakubovich D, Oh A, Su S, Da X, Lavi A, Kimelman-Bleich N, Zilberman Y, Li N, Bae H, Gazit Z, Pelled G, Gazit D. Gene-modified adult stem cells regenerate vertebral bone defect in a rat model. Mol Pharm. 2011; 3;8(5):1592-601.
• Connors MJ, Ehrlich H, Hog M, Godeffroy C, Araya S, Kallai I, Gazit D, Boyce M, Ortiz C. Three-dimensional structure of the shell plate assembly of the chiton Tonicella marmorea and its biomechanical consequences. J Struct Biol. 2012 Feb;177(2):314-28.
• Kimelman Bleich N, Kallai I, Lieberman JR, Schwarz EM, Pelled G, Gazit D. Gene therapy approaches to regenerating bone. Adv Drug Deliv Rev. 2012;64(12):1320-30.
• Mizrahi O, Sheyn D, Tawackoli W, Kallai I, Oh A, Su S, Zarrini P, Cook-Wiens G, Gazit D, Gazit Z. BMP-6 is More Efficient in Bone Formation Than BMP-2 When Overexpressed in Mesenchymal Stem Cells. Gene Ther. 2013;20(4):370-7.
• *Pelled G, Mizrahi O, Kimelman-Bleich N, Gazit D. Mesenchymal Stem Cells for Bone Gene Therapy. Chapter 7 in: Principles of Bone Regeneration. Sela J. and Bab I. Eds. Springer Inc, 2012.
• Pelled G, Snedeker JG, Ben-Arav A, Rigozzi S, Zilberman Y, Kimelman-Bleich N, Gazit Z, Müller R, Gazit D. Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the achilles tendon. J Orthop Res. 2012;30(12):1932-9.
• Ben Arav A, Pelled G, Zilberman Y, Kimelman-Bleich N, Gazit Z, Schwarz EM, Gazit D. Adeno-Associated Virus–Coated Allografts: A Novel Approach for Cranioplasty. J Tissue Eng Regen Med. 2012;6(10):e43-50.
• Benjamin S, Sheyn D, Ben-David S, Oh A, Kallai I, Gazit D, Gazit Z. Oxygenated Environment Enhances Both Stem Cell Survival and Osteogenic Differentiation. Tissue Eng Part A. 2013;19(5-6):748-58.
• Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su S, Li N, Oh A, Bae H, Gazit D, Gazit Z. Nucleus pulposus degeneration alters properties of resident progenitor cells. Spine J. 2013;13(7):803-14.
• Sheyn D, Pelled G, Tawackoli W, Su S, Ben-David S, Gazit D, Gazit Z. Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation. Regen Med. 2013;8(3):295-308.
• Liu Q, Jin N, Fan Z, Natsuaki Y, Tawackoli W, Pelled G, Bae H, Gazit D, Li D.  Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T. NMR Biomed. 2013;26(12):1672-9.
• Kimelman NB, Kallai I, Sheyn D, Tawackoli W, Gazit Z, Pelled G, Gazit D. Real-time bioluminescence functional imaging for monitoring tissue formation and  regeneration. Methods Mol Biol. 2013;1048:181-93.
• Sheyn D, Cohn Yakubovich D, Kallai I, Su S, Da X, Pelled G, Tawackoli W, Cook-Weins G, Schwarz EM, Gazit D, Gazit Z. PTH promotes allograft integration in a calvarial bone defect. Mol Pharm. 2013;10(12):4462-71.
• *Gazit Z, Kimelman-Bleich N, Mizrahi O, Gazit D. Gene Therapy Approaches for Disc Regeneration. Chapter 24 in: The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease. Editors: Shapiro, Irving M., Risbud, Makarand V. (Eds.). Springer-Verlag Wein, 2014.
• Antebi B, Pelled G, Gazit D. Stem cell therapy for osteoporosis. Curr Osteoporos Rep. 2014;12(1):41-7.
• Shapiro G, Kallai I, Sheyn D, Tawackoli W, Koh YD, Bae H, Trietel T, Goldbart R, Kost J, Gazit Z, Gazit D, Pelled G. Ultrasound-mediated transgene expression in endogenous stem cells recruited to bone injury sites. Polym. Adv. Technol. 2014;25: 525–531.
• Liu Q, Tawackoli W, Pelled G, Fan Z, Jin N, Natsuaki Y, Bi X, Gart A, Bae H, Gazit D$, Li D$. Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R(1ρ) dispersion and -OH chemical exchange saturation transfer (RROC). Magn Reson Med. 2015;73(3):1196-205.. [$equal senior authors]
• Navaro Y, Bleich-Kimelman N, Hazanov L, Mironi-Harpaz I, Shachaf Y, Garty S, Smith Y, Pelled G, Gazit D, Seliktar D, Gazit Z. Matrix stiffness determines the  fate of nucleus pulposus-derived stem cells. Biomaterials. 2015;49:68-76.
• Lavi A, Pelled G, Tawackoli W, Casap N, Gazit D, Gazit Z. Isolation and characterization of mesenchymal stromal progenitors from the temporomandibular joint disc. J Tissue Eng Regen Med. 2015, In press.
• Pelled G, Sheyn D, Tawackoli W, Jun DS, Koh YD, Su S, Oh A, Da X, Kallai I, Yakubovich D, Gazit Z, Bae H, Gazit D. Allogeneic, BMP6 gene-modified, bone marrow MSCs induce vertebral defect repair in a porcine model. Stem Cell Int. 2016, In press.
• Cohn-Yackubovich D, Tawackoli W, Sheyn D, Kallai I, Da X, Pelled G, Gazit Z, Gazit D. Computed tomography and optical imaging of osteogenesis-angiogenesis coupling to assess integration of cranial bone autografts and allografts. J Vis Exp. 2015, (106).
• Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Kang KB, Su S, Da X, Ben-David S, Bez M, Yalon E, Antebi B, Avalos P, Stern T, Zelzer E, Schwarz EM, Gazit Z, Pelled G, Bae HM, Gazit D. PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries. Mol Ther 2016;24(2):318-30.
• Shapiro G, Wong AW, Bez M, Yang F, Tam S, Even L, Sheyn D, Ben-David S, Tawackoli W, Pelled G, Ferrara KW, Gazit D. Multiparameter evaluation of in vivo  gene delivery using ultrasound-guided, microbubble-enhanced sonoporation. J Control Release. 2016;10;223:157-64.
* Chapter in a book.

 
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