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  • Dr.  Miriam Haisraeli - Shalish
1963 Born, Israel
1984 B.Sc., Hebrew University, Israel
1987 D.M.D., Hebrew University, Israel
1993-1996 Post-graduate program, specializing in Orthodontics, Tel Aviv University, Israel
1997 Specialist in Orthodontics, Israel
1997 Clinical Instructor, Tel Aviv University, Israel
2000 Visiting Lecturer, Harvard University, USA
2002 Director, Predoctoral Orthodontics, Harvard University, USA
2002 Director, Postdoctoral Orthodontic Clinic, Harvard University, USA
2002 Instructor, Harvard University, USA
2004 Assistant Professor of Oral and Developmental Biology (Orthodontics),
Harvard School of Dental Medicine, Harvard University , USA
2009 Clinical Lecturer, Hebrew University, Israel
2012 Director, International Postdoctoral Orthodontic Program,
Hebrew University – Hadassah School of Dental Medicine
20015 Clinical Senior Lecturer, Hebrew University, Israel
The future of the field of Orthodontics depends on our ability to adopt new research methodologies combining clinical orthodontics with genetics and applying them to advance orthodontic research into new bold areas. Along this line, my research has been progressing in two paths: clinical studies and basic science:
I. Clinical Research
We have established a new dental anomaly, expressed in a distal inclination of the mandibular second premolar (MnP2). We have shown clear associations between this anomaly and various other dental anomalies already established to be of genetic origin. By that we have shown the genetic trait of this anomaly, suggesting several genes as possible causes. At present, we continue collecting data to study association with other known anomalies and also to build a data base for classification of the MnP2 distal inclination anomaly.
We are interested in finding the etiology of palatally impacted canines (PDC). PDC is a dental anomaly, occurring in 1-3% of the general population. It leads to uneruption of a permanent tooth and may cause root resorption of adjacent teeth. Treatment is complicated as it requires a combination of orthodontics and surgery. In collaboration with Prof. Chaushu, Prof. Elpeleg and Dr. Golbert, we are conducting a research project, funded by the Research Fund of Hadassah School of Dental Medicine, to identify the mode of inheritance and the genes causing PDC. The outcome of this study will assist in early diagnosis and prevention of the PDC anomaly.
II. Basic Science Research
Genetic influences on bone remodeling: In this study, we use orthodontic tooth movement in mice to induce bone remodeling. Our model is based on the histological comparison of orthodontically induced bone remodeling between wild-type mice and mutant mice, in which a certain gene has been “knocked out.” This model should help us understand the role of this specific gene in the process of bone remodeling, which is the basic natural process enabling orthodontic treatment.
We also collaborate with Prof. Isaac Ginsburg in a series of studies on saliva, which has become an important research field in oral physiology and pathology. The oxidant-scavenging abilities in the oral cavity may be regulated by a “cross-talk” among antioxidants in saliva, microorganisms and blood cells We are conducting a chemiluminescence-based study to investigate the influence of orthodontic treatment on this cross-talk.
Ginsburg I, Koren E, Feuerstein O, Zogakis IP, Shalish M, Gorelik S. Chlorhexidine markedly potentiates the oxidants scavenging abilities of Candida albicans.  Inflammopharmacology, 2015;Jul 31. [Epub ahead of print]
Shalish M, Dykstein N, Friedlander-Barenboim S, Ben-David E, Gomori JM, Chaushu S. Influence of common fixed retainers on the diagnostic quality of cranial magnetic resonance images. Am J Orthod Dentofacial Orthop, 2015;147:604-9
Shalish M, Will LA, Fukai N, Hou B, Olsen BR. Role of polycystin-1 in bone remodeling: Orthodontic tooth movement study in mutant mice. Angle Orthod, 2014;84:885-90
Shalish M, Har-Zion G, Zini A, Harari D, Chaushu S. Deep submersion: severe phenotype of deciduous-molar infraocclusion with biological associations. Angle Orthod, 2014;84:292-6.
Ginsburg I, Kohen R, Shalish M, Varon D, Shai E, Koren E. The oxidant-scavenging abilities in the oral cavity may be regulated by a ”cross-talk” among antioxidants in saliva, microorganisms, blood cells and polyphenols: A Chemiluminescence-based study. PLOS ONE, 2013;8(5) e63062.
Cooper-Kazaz R, Ivgi I, Canetti L, Tsur B,  Bachar E, Chaushu S, Shalish M. The impact of personality on adult patients' adjustability to orthodontic appliances. Angle Orthod, 2013;83:76-82.
Zogakis IP, Shalish M, Greco PM. The Hippocratic Oath in perspective: "The 6 keys to ethical orthodontics?" [Editorial]. Am J Orthod Dentofacial Orthop, 2013;144:324-5
Shalish M, Gal A, Brin I, Zini A, Ben-Bassat Y. Prevalence of dental features indicating early orthodontic treatment. Eur J Orthod, 2013;35:454-9.
Ginsburg I, Koren E, Shalish M, Kanner J, Kohen R. Saliva increases the availability of lipophilic polyphenols as Antioxidants and enhances their retention in the oral cavity. Arch Oral Bio, 2012;57:1327-34.
Shalish M, Cooper-Kazaz R, Ivgi I, Canetti L, Tsur B,  Bachar E, Chaushu S. Adult Patients' Adjustability to Orthodontic Appliances. Part I: a comparison between Labial, Lingual, and Invisalign. Eur J Orthod, 2012;34:724-30.
Yitschaky O, Yitschaky M, Friedman M, Haisraeli-Shalish M. Are you afraid of open bite? Refuat Hapeh Vehashinayim, 2011;28:19-25.
Peck S, Shalish M. Dental anomalies, infraocclusion and the tongue: authors’ response [letter]. Angle Orthod, 2010;80:i after 990. 
Harari D, Redlich M, Shalish M, Hamud T, Gross M. The effect of mouth breathing versus nasal breathing on dentofacial and craniofacial development in orthodontic patients. Laryngoscope, 2010; 120:2089-93.
Shalish M, Peck S, Wasserstein A, Peck L. Increased occurrence of dental anomalies associated with infraocclusion of deciduous molars. Angle Orthod, 2010;80:440–445. 
Gazit-Rappaport T, Haisraeli-Shalish M, Gazit E. Psychosocial reward of orthodontic treatment in adult patients. Eur J Orthod, 2010;32:441–446.
Shalish M, Chaushu S, Wasserstein A. Malposition of unerupted mandibular second premolar in children with palatally displaced canines. Angle Orthod, 2009;79:796-9.
Shalish M, Will LA, Shusterman S. Malposition of unerupted mandibular second premolar in children with cleft lip and palate. Angle Orthod, 2007;77:1062–6.
Wasserstein A, Brezniak N, Shalish M, Heller M, Rakocz M. Angular changes and their rates in concurrence to developmental stages of the mandibular second premolar. Angle Orthod, 2004;74:332-6.
Wasserstein A, Shalish M. Adequacy of mandibular premolar position despite early loss of its deciduous molar. ASDC J Dent Child, 2002;69:254-8.
Shalish M, Peck S, Wasserstein A, Peck L. Malposition of unerupted mandibular second premolar associated with agenesis of its antimere. Am J Orthod Dentof Orthop, 2002;121:53-6. Selected as Editor's choice
Haisraeli-Shalish M, Livne A, Katz J, Doolman R, Sela B-A. Recurrent aphtous stomatitis and thiamine deficiency. In Yearbook of Dentistry, Meskin LH., Berry TG, Jeffcoat MK, Leinfelder KF. Roser SM, Summitt JB, Zakariasen KL (Eds.), Mosby, St. Louis , 1998, pp.151-2.
Haisraeli-Shalish M, Livne A, Katz J, Doolman R, Sela B-A. Recurrent aphtous stomatitis and thiamine deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1996; 82:634-6.
Deutsch D, Haisraeli M, Palmon A, Arad A, Alayoff A. Separation, purification and characterization of enamel proteins using HPLC, 2D electrophoresis and specific polyclonal antibodies. In Current Advances in Skeletogenesis/3, S. Hurwitz and J. Sela (Eds.) Heiliger Publ. Co., Jerusalem , 1986, pp.169-75.
Deutsch D, Haisraeli M, Palmon A, Arad A, Alayoff A. Separation, Purification and Characterization of Enamel Proteins, using HPLC, 2D-Electrophoresis, Limited Proteolysis and Specific Polyclonal Antibodies. Bone, 1986; 7 (5): 408-408.
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